Acute inflammatory reaction after subcutaneous implantation of titanium with micro-nano surface
MENG Fan-hui
WANG Jin-jin
ZHANG Yu-mei
Abstract：AIM:To observe the acute inflammation induced by titanium with different surface topography. METHODS:The titanium samples with the surface topography of smooths,micro concavity,nanotubes with the diam-eter of 20~30 nm and 80 ~100 nm were subcutaneously implanted into C57 mice(n=6) respectively. 16 and 72 hours after operation the skin and subcutaneous tisure samples were taken and examined by HE staining,toluidine blue staining and immunohistochemistic test. RESULTS:The smooth sample group showed more inflammatory cell infiltra-tion than the other 3 groups(P<0.05), micro concavity group showed more inflammatory cell infiltration than the 2 nanotube groups(P<0.05),no statistical difference was observed between the 2 nanotube groups. CONCLUSION:Implant surface topography may play a role in subsequent acute inflammation reaction.
Keywords：pure titaniumsurface topographysacute inflammationneutrophilmast cellsbcutaneous im-plantation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 14-19 )