GDF11 inhibits bone formation of aged mice: an experimental study
ZHU Biao
JIAO Ting
ZHAO Gang
ZHANG Jia-jia
GUO Xi-min
GUO Hong-yan
XIANG Guang-da
Abstract：AIM:To investigate the effect of GDF11 on bone metabolism of aged mice.METHODS:Twenty 18-month old C57 mice were randomly divided into GDF11 group (0.3 mg · kg-1 · d-1 intraperitoneal injection,n =10) and Vehi group (equivalent physiological saline,n =10),4 weeks after intervention,biochemical marks of bone metabolism were tested and histomorphometric indexes of femurs were measured by microcomputed tomography.RESULTS:GDF11 decreased biochemical marks of bone formation including COL-1 and OCN;increased the expression of PPAR-γ;enhanced the histomorphologic indexes of osteoporosis of femurs.CONCLUSION:GDF11 inhibits bone formation of old mice.
Keywords：GDF11BMSCsosteoblastosteoporosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 623-628 )