The role of OPG/RANKL/RANK system in oral and maxillofacial region
JIANG Qiu-ying
Abstract：Physiologically, bone metabolism is the constant process of osteoblasts-mediated bone formation and osteoclasts-mediated bone resorption.A variety of cytokines and growth factors are involved in both processes.In recent years, the discovery of OPG/RANKL/RANK system which is composed of osteoprotegerin(OPG), receptor activator of NF-κB ligand(RANKL) and the receptor activator of NF-κB(RANK) leads to a great advance in researches of bone physiology.The OPG/RANKL/RANK triad belongs to the tumor necrosis factor family.With deep study of OPG/RANKL/RANK system, we found the system can provide useful insights for multiple disciplines in dental field.
Keywords：osteoprotegerin(OPG)receptor activator of NF-κB ligand(RANKL)receptor activator of NF-κB(RANK)
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 483-487 )