Fabrication of PLA-CS/Emodin nanofibers membrane by co-electrospinning
ZHU Wen-zhong
MA Zhi-wei
Abstract：AIM:To prepare a novel Polylactide (PLA)-chitosan(CS)/emodin nanofibrous membrane and to evaluate the physical and chemical properties of PLA-CS/Emodin.METHODS:Nanofibrous membrane with PLA-CS/Emodin was preparedb by co-electrospinning technology (test group) and traditional electrospinning method (the control group) respectively.Then morphology and coaxial structure was observed by SEM, the mechanical properties and emodin release rate were examined by biomechanic tester and HPLC respectively.RESULTS:The fiber of the test group was uniformly distributed and the surface of fibers was smooth.The diameter was(927±73)nm,and the tensile strength (4.62±0.58)MPa,the elastic modulus(13.73±2.64)MPa, emodin release rate was lower than that of the control(P<0.05)and the release kept for more than 15 d.The mechanical properties of the test group were different from those of the control group.CONCLUSION:The PLA-CS/Emodin fiber presents outstanding mechanical properties and sustained-release properties.
Keywords：polylactidechitosanemodinelectrospinningGTR
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 454-458 )