A study of bactericidal efficacy of KSL antimicrobial peptides chewing gum on oral bacteria by 16S rRNA sequencing technique
ZHAO Ze
LI Zong-ze
ZHANG Wen-fei
XIANG Dou-dou
TIAN Yu
YU Qing
Abstract：AIM:To investigate the bactericidal effect of KSL antimicrobial peptides chewing gum on oral bacteria by 16S rRNA sequencing technique.METHODS:Saliva samples were collected before and after using KSL antimicrobial peptides chewing gum from 6 healthy subjects.Saliva samples′ DNA was extracted and the 16S ribosomal RNA gene clone library was constructed. The composition and abundance of bacteria before and after chewing the gum were analyzed.RESULTS:A total of 375 OTUs were obtained.At phylum level, KSL antimicrobial peptides chewing gum showed significant inhibiting effect on Proteobacteria, Bacteroidetes and Firmicutes(P<0.05).At genus level, the chewing gum showed significant inhibiting effect on Bacteroides, Neisseria, Haemophilus, Veillonella, Prevotella and Streptococcus(P<0.05).CONCLUSION:KSL antimicrobial peptides chewing gum has bactericidal effect on most pathogenic bacteria of dental caries and periodontal disease.
Keywords：16Sribosomal RNAKSL antimicrobial peptidesoral microorganismsbactericidal effect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 387-390 )