Study on E-selectin gene polymorphism in Uyghur and Han nationalities in Urumchi
MA Ya-ping
NIU Qiao-li
CHEN Ling
YU Xian-mei
Abstract：AIM:To explore the gene polymorphisms distribution of E-selectin gene SNP rs5361 in Uyghur and Han nationalities in Urumqi, Xinjiang.METHODS:185 oral epithelial cell samples were collected from Uyghur(n=98) and Han subjects(n=87), gene sequencing was performed after whole-genome DNA extraction, the distribution of gene polymorphisms was compared between the 2 nationalities.RESULTS:For the Uyghur nationality in Urumchi, the frequencies of rs5361AA, AC and CC gene types were 77.6%,21.4% and 1.0%, the allele frequency of A/C were A=84.9% and C=15.1%;for the Han nationality the frequencies of rs5361AA, AC and CC gene types were 92.0%, 8.0% and 0.0%, the allele frequency of A/C was A=96.0% and C=4.0%, respectively(x2=7.475/7.037, P=0.024/0.008).CONCLUSION:The gene polymorphism distribution of SNP rs5361 in Uyghur nationalitiy in Urumchi is different from that in Han nationality.
Keywords：E-selectinperiodonticssingle nucleonic polymorphisms
Publication Date：2017-01-01
Pages：4( 378-381 )