The effects of HMME-PDT with different power density on the prevention of dental caries in rat model
MA Ying-ying
ZOU Zhao-hui
LI Min
ZHANG Lei
Abstract：AIM: To evaluate the inhibitive effect of photodynamic therapy(PDT) with different power density on dental caries formation in rats.METHODS:56 Wistar rats (aged 21 days) were infected with S.mutans for the establishment of rat caries mode1s and then divided in to 7 groups(n=8).As controls, the rat''s teeth were treated with 9 mL/L NS, and 2 g/L NaF respectively.The laser, hematoporyrin monomethyl ether(HMME) and laser plus HMME were respectively used to treat the teeth in the treatment groups, The rats'' teeth were treated once a week for 4 weeks.Then the rats were sacrificed and Keyes count method was used to evaluare the inhibitory effect of PDT on dental caries.RESULTS: The PDT-treated teeth and NaF-treated teeth showed significantly reduced Keyes scores than the negative controls, laser-treated and HMME-treated teeth(P<0.05).Keyes scores of 70 mw/cm2 HMME-PDT group was higher than that of NaF-treated teeth (P<0.05).Keyes scores of 140 mw/cm2 HMME-PDT group was the same as that of NaF-treated group(P>0.05), Keyes scores of 280 mw/cm2 HMME-PDT group was less than that of NaF-treated group (P<0.05).Keyes scores reduced with the increase of the laser power dentistry.CONCLUSION: HMME-PDT may inhibite caries development in a laser power density dependent manner.
Keywords：power densityhematoporyrin monomethyl ether(HMME)photondynamic treatment(PDT)keyes count
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 320-325 )