Establishment of mouse model of orthodontic tooth movement
Abstract：AIM: To establish mouse model of orthodontic tooth movement.METHODS: 30 male C57 mice aged 10 weeks were randomly divided into 0,1,3,5 and 7 d groups(n=6).The right side of jaws attached with orthodontic appliances were used as the experiment group.In the movement progress,the mice were regularly checked and the loss rate of the orthodontic tension spring was calculated.The mice in each group were executed at the corresponding time,the iaw samples were taken and fixed,the movement of the teeth was observed by CT scanning.HE staining and immunofluorescence staining were used to observe the bone remodeling.RESULTS: CT results showed that the teeth were obviously moved.HE staining showed that there was bone remodeling in the pressure side,and immunofluorescence staining showed that at the pressure side there the periodontal membrane became narrow,osteoclasts were observed.CONCLUSION: The mouse model of orthodontic tooth movement is established.
Keywords：tooth movementorthodontic treatmentanimal modelmouse
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 280-283 )