Interleukin-17 and interleukin-18 level in gingival crevicular fluid of the pationts with chronic periodontitis
JIANG Yan-jun
MU Ling-dan
MU Tong
ZAHNG Yu
Abstract：AIM:To study the level of IL-17 and IL-18 in gingival crevicular fluid (GCF) in patients with chronic periodontitis(CP).METHODS:20 patients with CP and 20 age-and gender-matched healthy subjects (aged 25-60 years) were included.GCF samples were collected from all subjects with Whatman 3M paper strip.Non-surgical periodontal therapy was performed for the patients.6 weeks after treatment,GCF samples were obtained again from the patients.Gingival index (GI),probing depth (PD),attachment loss (AL) and bleeding index (BI) were assessed.The levels of IL-17 and IL-18 in all the GCF samples was determined by ELISA.RESULTS:IL-17 and IL-18 levels were significantly higher in GCF of the patients than those in healthy subjects before and after treatment(P<0.05).In patients they were decreased significantly after periodontal therapy (P<0.05).All periodontal parameters were ameliorated after periodontal treatment(P<0.05).IL-17 and IL-18 levels were positively correlated with IL-17,IL-18 levels and periodontal destruction.CONCLUSION:IL-17 and IL-18 can be indexes for periodontal health.
Keywords：chronic periodontitis(CP)interleukin-17interleukin-18gingival crevicular fluidELISA
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 224-227 )