Preparation of OPG-PLA/CS nanofibermembranes by coaxial electrospinning and its characterization
SHI Chen-nan
LIU Jia
WANG Feng
XU Hong-yu
Abstract：AIM:To prepare a novel osteoprotegerin(OPG)-polylactide (PLA)/chitosan(CS)nano-fibrous membrane by coaxial electrospinning,and to evaluatethe biological properties of the OPG-PLA /CS fiber.METHODS:A nanofibrous membranes with OPG-PLA/CS and PLA/CS were respectively prepared by coaxial electrospinning method.The morphology,mechanical properties and plasmid release rate of the membranes were observed and evaluated.RESULTS:The OPG-PLA/CS fiber diameter was uniform and the surface of the fiber was smooth.The diameter of OPG-PLA/CS and PLA/CS was(468±53)nm and (375±65)nm(P<0.05),the tensile strength was(1.85±0.37)MPa and(4.23±0.51)MPa(P<0.05),the Young's modulus was (12.58±1.73) MPa and (13.26±2.79)MPa (P>0.05),respectively.The release of plasmid was going on for more than 30 d and stable.CONCLUSION:The OPG-PLA/CS fiber prepared by coaxial electrospinning method may have excellent mechanical property and controlled release of plasmid.
Keywords：polylactide(PLA)chitosan(CS)osteoprotegerin(OPG)coaxial electrospinningguided tissue regeneration
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 141-144 )