Levels of CHI3L1 and CHIT1 in saliva and plasma of patients with periodontal diseases after non-surgical periodontal treatment
LI Xin
XIANG Zhao
LIANG Shuang
LI Peng-fei
ZHANG Hui-yu
ZHANG Gang
Abstract：AIM:To study the expression of Chitinase 3-like protein 1 (CHI3L1) and chitotriosidase (chitinase-1,CHIT1) in saliva and plasma of patients with periodontal diseases after non-surgical periodontal treatment,and to investigate their potential roles and clinical significance in the progress of periodontitis.METHODS:Patients with chronic periodontitis (CP) (n =27),chronic gingivitis (CG) (n =17) and the individuals with periodontal healthy (PH) (n =20) were enrolled.The levels of CHI3L1 and CHIT1 in saliva and plasma were analyzed by ELISA in CP and CG patients before and 1 month after non-surgical periodontal treatment.RESULTS:The salivary CHI3L1 level in CP patients was higher than that in PH individuals (P ＜ 0.05).After non-surgical periodontal treatment,the saliva level of CHI3L1 in CP patients decreased (P ＜ 0.05).However,there was no significant difference in salivary CHI3L1 level in CG group before and after treatment.No significant change of CHIT1 level was found in salivary and plasma in all groups.CONCLUSION:CHI3 L1 may be used as a potential marker in evaluating the progress of chronic periodontitis.
Keywords：chronic periodontitischitinase 3-like protein1 (CHI3L1)chitotriosidase (CHIT1)non-surgical periodontal treatment
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 12-15 )