The expression of heat shock protein 27 and heat shock factor 1 in pulp tissues of experimental pulpitis
WU Xiao-lian
ZHANG Sheng-dan
WEI Ya-juan
ZHAO Yuan
Abstract：AIM:To observe the expression of heat shock protein 27 (HSP27) and heat shock factor 1 (HSF1) in rat dental pulps with experimental pulpitis.METHODS:The pulp chamber of the maxilar 1 st and 2nd molaxs of Wistar rats was opened by a dental bur for the establish ement of experimental pulpitis.The rats were sacrificed on d 1,3,5,7 and 10 after pulp exposure.Maxillary molars with surrounding bone were taken and subjected to immunohistochemical staining for the observation of the expression of HSP27 and HSF1.RESULTS:HSP27 was moderately expressed at the odontoblast layer in normal rat dental tissus.In the middle stage of pulpitis,positive staining of HSP27 was found in odontoblasts,fibroblasts,endothelial cells,smooth muscle cells of the vessel walls and in reparative dentin.The intensity of HSP27 expression increased with the development of pulpitis.However,no HSF1 expression was found in normal and inflammatory pulp tissues.CONCLUSION:HSP27 might be positively related to the development of pulpitis and play a role in the dental pulp repair and in the formation of reparative dentin.HSF1 may have no significance in the progress of pulpitis.
Keywords：heat shock protein 27 (HSP27)heat shock factor1 (HSF1)immunohistochemistrypulpitis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 7-11 )