Relationship of E-selectin S128 R genetic polymorphisms with chronic periodontitis and coronary heart disease
LUO Zhi-xiao
LI Jing
AI Jun
JIANG Ling
CHEN Rui
Abstract：AIM:To investigate the relationship of E-selectin S128R genetic polymorphisms with the sus-ceptibility of chronic periodontitis(CP) and coronary heart disease(CHD). METHODS: A case-control study was conducted. DNA was obtained from the blood of 82 patients with CP,76 with CHD,75 with CP and CHD, and 80 matched healthy controls. Genotypes of S128R polymorphism was analyzed by PCR-PFLP method. The genotype distri-bution of the 4 groups was compared. RESULTS:Higher representation of S128R allele R was found in CHD and CP group than that in the healthy control individuals,and there was statistical differences among the 4 groups(P<0. 05). CONCLUSION:E-selectin S128R genetic polymorphism is related to the incidence of CHD and CP. Allele R of S128R may be associated with CHD and CP susceptibility.
Keywords：E-selectinchronic periodontitiscoronary heart diseasegene polymorphism
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 712-715 )