Age-related changes of heat shock protein expression in the dental pulp of SD rats
LI Rui-min
ZHANG Jing
LI Xiao-jie
DONG Wen-liang
GONG Juan
ZHAO Li-ping
Abstract：AIM:To investigate the age-related changes of heat shock protein( HSP) expression in dental pulp tissue. METHODS:Male SD rats with the ages of > 10 m (n=15) and < 2 m (n=15) were used in this study. The mandibles with the bilateral first molars were sectioned, fixed and decalcified. The expression of heat shock transcription factor 1 (HSF1) and heat shock protein 27 (HSP27) in the dental pulp tissues were examined by immu-nohistochemical staining, RT-PCR and Western blot. RESULTS:Both HSF1 and HSP27 were expressed in the dental pulp tissues of SD rats. The mRNA and protein expression of HSF1 increased with age. However, the mRNA and pro-tein expression of HSP27 decreased with age. CONCLUSION:Heat shock protein might be involved in the process of dental pulp ageing.
Keywords：dental pulpage-related changeheat shock protein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 708-711,732 )