Runx2,Osx and DSPP expression after dental pulp injury in SD rats
DOU Yu-xin
WANG Fei
KONG Tao
FENG Yu-ling
LI Shi-ting
TAN Ying-hui
Abstract：AIM:To observe the expression of Runx2,Osx and DSPP after dental pulp injury in SD rats. METHODS:24 male SD rats were randomly divided into control(n =4)and dental pulp injury groups(n =20).The pulp of the bilateral mandibular first molars in injury model groups was exposed.At 0 h,3 h,12 h,3 d and 7 d after dental pulp exposure the animals(n =4)were perfused to death.The teeth were sectioned and the expression of Runx2,Osx and DSPP was observed using HE staining and immunofluorescence.RESULTS:Reparative dentine for-mation was detected at the 7th after pulp injury.The expression of Runx2,Osx and DSPP was mainly at the bottom of dental pulp injury site.The expression of Runx2 was the strongest at the 3rd after injury(P <0.05)and then gradually declined.The expression of Osx and DSPP showed a trend of gradual increase.The expression of Osx was the strongest at the 7th after injury.(P <0.05),while the expression of DSPP reached peak at the 3rd after injury and remained constant(P <0.05).CONCLUSION:Runx2,Osx and DSPP show different expression patterns in different periods after dental pulp injury .
Keywords：Runx2OsxDSPPdental pulp cellsreparative dentine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 277-282,266 )