Correlation between cystic fibrosis and abnormal enamel
TAO Wen-jing
WU Jia-yuan
Abstract：Cystic fibrosis ( CF) is a systemic disorder commonly seen in Caucasian in approximately one out of 2,500 live births. Clinical data show that there is also a certain incidence of the disease in China. The etiology of CF is that mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR) gene cause dysfunction of CFTR protein. Studies have found a higher prevalence of enamel defects but a lower dental caries incidence in CF pa-tients than in healthy population, and CF mice has chalky white incisor enamel. Further molecular studies have shown that the CFTR gene is associated with abnormal development of incisors. Specific oral manifestations may be risk indi-cators of systemic disorders. This article is committed to review the enamel abnormalities and related research of CF.
Keywords：cystic fibrosiscystic fibrosis transmembrane conductance regulator ( CFTR)enamelpH regula-tiondental fluorosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 688-691,697 )