The inhibitory effect of icariin on root resorption induced by rapid palatal expansion
WANG Feng
LIU Zhi-feng
LIU Yi
LU Huai-xiu
LIN Song-shan
Abstract：AIM:To investigate the inhibitory effect of icariin on root resorption induced by rapid palatal ex-pansion in rats. METHODS:24 male Wistar rats were divided randomly into 3 groups (n=8) as group A (negative control) , B ( positive control) and C ( experimental) . In group B and C, an initial force of 50 g was applied to the area between the right and left upper first molars of the rats for 21 d for palatal expansion. The rats in group C were given in-tragastric administration of icariin at 2. 5 mg /kg/d while the rats in group A and B were given the same dose of place-bo. 21 days after treatment the rats were sacrificed and the centered buccal-lingual root and peridentium tissue slices were generated from the upper first molars of the rats and were examined with HE and tararate-resistant acid phospha-tase staining. Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) expression was determined by immunohistochemistry. RESULTS: Compared with group A and B, the number of osteoclass in group C decreased (P<0. 05), the OPG/RANKL expression increased (P<0. 05). CONCLUSION: Icariin may inhibit rapid palatal expansion-induced root resorption through increasing OPG/RANKL expression and decreasing os-teoclast formation.
Keywords：icariinroot resorptionorthodonticsrapid palatal expansionosteoclast
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 404-407,411 )