Regulatory effects of adrenergic signals on the function of immune cells in chronic periodontitis
HE Tao
LI Meng
CHEN Hai-wen
SUI Bing-dong
LIU Qi
ZHAO Xin-yi
Abstract：In the development of chronic periodontitis, the mechanisms of the destruction of periodontal tis-sues include direct damages caused by bacteria and inflammatory reactions of the host, of which the inflammation has been recognized to play a key role. The host immune reactions protect against bacterial plaques and their toxic prod-ucts. However at the same time, the persistent abnormal activation of immune reactions results in overproduction of pro-inflammatory cytokines, leading to resorption of the alveolar bone. For now, activation of sympathetic nervous system ( SNS) by emotional stress has become a major risk factor for chronic periodontitis. Many studies have discov-ered regulatory capacity of norepinephrine (NE), the primary neurotransmitter secreted by SNS, on the functions of immune cells, thus the host SNS directly or indirectly participates in the development of chronic periodontitis. This re-view focuses on the regulatory effects of adrenergic signals on the function of immune cells in chronic periodontitis.
Keywords：sympathetic nervous systemadrenergic receptorimmune cellschronic periodontitis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 378-383,347 )