Alpha-tricalcium phosphate/atelocollagen sponge composite versus autogenous bone for bone repair efficacy
LI Pei-qi
WU Bu-ling
GAO Jie
FANG Yi-ru
MATSUMOTO Naoyuki
HASHIMOTO Yoshiya
LIAO Wen
Abstract：AIM:To study the effects ofα-tricalcium phosphate(α-TCP)/atelocollagen sponge composite in the repair of calvarial defects in rats.METHODS:Bone defects (diameter,8 mm;depth,1 .0 mm)were created in 28 male SD rats aged 8 weeks .The rats were divided into 3 groups.Inα-TCP group(n=12)the bone defects were filled with α-TCP /atelocollagen sponge composite,in positive control group (n=12)with autogenous bone,in blank control group (n=4)with nothing.The rats in α-TCP and positive control groups were euthanized at 4,6,and 8 weeks after surgery respectively(n=4).The rats in blank control group (n=4)were euthanized 8 weeks after surger-y.The calvarial bone was scanned by micro-CT.HE TRAP and ALP staining were performed for the evaluation of new bone formation.RESULTS:Micro-CT images at 8 weeks after surgery revealed that,in α-TCP and positive control groups the bone volume was as (69.7 ±3.95)%and (42.475 ±4.38)%respectively(P<0.05).Histological anal-ysis revealed that in α-TCP group new bone contiguous with original bone was observed and the composite was ab-sorbed.In positive control group lot of osteoclasts and absorption of the transplanted autogenous bone were observed.In blank control group little new bone was observed at the boundary of the deffects.CONCLUSION:α-TCP /atelocolla-gen sponge composite is effective in the repair of bone defect.
Keywords：critical defectα-tricalcium phosphate/atelocollagen sponge compositeautogenous bone
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 223-228 )