A pilot study of biocompatibility of magnesium alloys
KANG Shuai
ZANG Sheng-qi
WAN Peng
HU Xin
WANG Jin-jin
ZHU Hong
LUO Lan-kun
XUE Peng
YANG ke
WANG Qin-tao
Abstract：AIM:To supply biocompatibility of three magnesium alloys.METHODS:The surface morphol-ogy of pure Mg (Mg ),AZ31 Mg alloy(AZ31)and microarc oxidation treated AZ31 alloy (MAO)was examined by SEM.Human periodontal ligament stem cells (hPDLSCs)were cultured on the surface of the samples,the cell prolif-eration was assayed by CCK-8 method and the cell morphology was examined by SEM.Then the samples were trans-planted subcutaneously into the back of SD rats.1,2,4 and 8 w after transplantation,the rats were sacrificed.The surface morphology of the samples was assayed by SEM and energy dispersive spectrometer (EDS),the foreign body reaction (FBR)was assessed by the reactive capsule thickness and the amount of macrophages.RESULTS:All 3 ma-terials showed inhibitory effects on hPDLSCs proliferation and adhesion,MAO group showed the least influence.In the in vivo test calcium and phosphorus contents on the surface of all materials increased significantly.Corrosion resistance was in the order of MAO>AZ3 1 >Mg.MAO group also demonstrated milder immune reaction than the other 2 groups. CONCLUSION:Microarc oxidation treatment can promote the biocompatibility and corrosion resistance of Mg.
Keywords：human periodontal ligament stem cellsmagnesium alloysmicroarc oxidationbiocompatibility
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 215-222,205 )