Expression and significance of EphA7 in inflamed human dental pulp
ZHAO Jun-jie
LAN Wei-dong
DONG Ying-chun
Abstract：AIM:To investigate the role of EphA7 gene in pulp inflammation and odontogenic pain. METHODS:18 healthy controls,18 asymptomatic and 18 symptomatic irreversible pulpitis human dental pulps were included in the study.The protein expression of EphA7 was detected by immunohistochemistry and western blotting re-spectively.RESULTS:In healthy samples,immunohistochemical staining showed that positive EphA7 expression was only in vascular endothelial cells and odontoblasts.In the inflammatory pulps ,EphA7 expression increased significant-ly.In addition to vascular endothelial cells and odontoblasts,EphA7 positive staining was also detected in fibroblasts, inflammatory cells and nerve fiber tissues.Western blotting analysis showed that EphA7 expression increased signifi-cantly in pulpitis samples compared with healthy controls.In symptomatic irreversible pulpitis samples,EphA7 expres-sion was significantly higher than those in asymptomatic ones.CONCLUSION:EphA7 gene may be a marker reflec-ting inflammatory and pain state of human dental pulp.
Keywords：EphA7dental pulppulpitisodontogenic pain
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 197-200 )