P2X3 receptor mRNA expression in human primary and permanent tooth pulp
JIN Li-mei
ZHAO Yu-mei
QI Ying
YU Fang
Abstract：Abstract] AIM:To investigate the relationship between dental pain and P2X3 receptor expression level. METHODS:14 normal permanent molars,10 normal primary teeth,12 pulpitis permanent molars and 12 pulpitis pri-mary teeth were included.An increase in metalloproteinase-9(MMP-9)was used to indicate pulpal inflammation in inflamed teeth.P2X3 receptor mRNA expression in tooth pulp was investigated using Real-Time fluorescence quantita-tive PCR.RESULTS:P2X3 receptor mRNA expression in normal and inflamed human permanent tooth pulp was simi-lar (P >0.05),whereas P2X3 receptor mRNA was up-regulated in inflamed primary dental pulp as compared with normal primary dental pulp (P <0.05).In addition,P2X3 receptor expression was greater in primary dental pulp than that in permanent dental pulp (P <0.05).CONCLUSION:P2X3 receptor may be related to primary tooth pulpitis pain.
Keywords：P2X3receptorspermanent teethprimary teethdental pulppain
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 133-136 )