Local treatment decreases the expression of CRP,ICAM-1 and E-selectins in periodontal tissue and serum of rats with experimental periodontitis
LI Chun-nian
DONG Fu-sheng
LI Shu-juan
WU Ming-xuan
LIU Qing
CHEN Rui-xue
Abstract：AIM:To study the expression changes of C reactive protein (CRP),intercellular adhesion mol-ecule-1 (ICAM-1)and E-selectin in periodontal tissue and in serum of rats with experimental periodontitis following local treatment.METHODS:Rat periodontitis model was established in 60 SD rats by periodontal ligation for 8 weeks.Then the ligation was removed and local treatment was conducted,the expression level of of CRP,ICAM-1 and E-selectin in the periodontal tissue and in serum was measured at 4,8 and 12 weeks respectively after local treatment (n =10).RESULTS:After local treatment the experimental periodontitis was eased (P <0.05),the expression lvel of CRP,ICAM-1 and E -selectin in periodontal tissue and serum was decreased in a time dependent manner (P <0.05).CONCLUSION:Periodontal treatment can reduce the expression of CRP,ICAM-1 and E-selectin ex-pression in periodontal tissues and serum.
Keywords：experimental periodontitislocal treatmentCRPICAM-1E-selectin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 95-99 )