Research progresses of the relationship between epigenetic and aging
BI Chun-sheng
ZHANG Lin-lin
CHEN Fa-ming
JIN Yan
Abstract：Aging is caused by a variety of factors, such as gene mutations in signaling pathways ( including insulin signaling pathway and WNT signaling pathways, etc.) , abnormal regulation of transcription factor, unusual chromosome and the change of external environment factors.Effect of environmental factors on aging is often accom-plished by changing chromosome state.The chromosome change is due to the change of physiological conditions, envi-ronmental stimuli, or some pathologic conditions.Compared to simple genetic mutations and abnormal regulation of transcription factors, the chromosome change is more persistent and more sustainable in the body, and can be inherited to the next generation.At present more attention is paid to the change of the gene expression level in the study of ag-ing.This paper reviews the progresses of the study on the relationship between epigenetic and aging.
Keywords：agingepigeneticsDNA methylationhistone modification
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 738-744 )