Experimental study on correlation between the 3.5th generation of polyamidoamine dendrimer action time and the occluding of dentinal tubules
WEI Xiao-lang
LI Qiu-rong
ZHOU Tong
XIE Fang-fang
Abstract：AIM: To evaluate the occluding ability of the 3.5 th generation of polyamidoamine dendrimer (PAMAM) on human dentinal tubules.METHODS:32 extracted human third molars were used to make sensitive dentin models and were divided into 4 groups (A, B, C and D) (n=8)randomly.The dentin models were treated with G3.5 PAMAM for 0(A), 1(B), 30(C) and 60(D) min respectively and subsequently immersed into artificial saliva for 2 weeks.The dentin discs were observed by Fouier Transform Infrared Spectroscopy ( FT-IR) , field emission scanning electron microscope ( FE-SEM) and energy dispersive spectrometer ( EDS) respectively.RESULTS:The oc-cluding depth (μm) in group B, C and D were 26.31 ±2.45, 25.34 ±2.57 and 30.36 ±2.15 respectively (P>0.05).The dentinal tubules in group A were all open.The Ca/P ratios were no significantly different among 4 groups (P>0.05).CONCLUTION:3.5 th generation of polyamidoamine dendrimer has occlusion effect on sensi-tive dentinal tubules.However, there was no significant correlation between its action time and the occluding capability.
Keywords：polyamidoamine dendrimerdentin hypersensitivitytooth remineralization
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 714-717,695 )