The anti-demineralization effect of hesperidin on human coronal dentin
WANG Dan-yang
RUAN Jian-ping
WANG Peng
QIN Si-jia
LI Xue
MA Xin-yang
Abstract：AIM: To investigate the anti-demineralization effect of hesperidin on human coronal dentine . METHODS:Extracted molars were sectioned into slices with the size of 4 mm ×3 mm ×2 mm.All 60 specimens were randomly divided into 5 groups according to different pretreatment solution .The dissolvant control was 1 000 mg/L NaOH. The negative control was double distilled water .The positive control was 1 000 mg/L NaF.The experimental groups were 7 000 mg/L and 3 500 mg/L hesperidin(HPN) solution.The pH cycling was employed on the specimens by incubation in testing solutions for 10 min, in orange juice for 1 h and in neutral buffer for 5 min.The pH cycling went for 7 days (2 times per day).The micro-hardness(SMH)was measured by a Vickers micro-hardness tester(n=6), and the lesion depth was evaluated by laser scanning confocal microscope ( n=6) .RESULTS:Before pH cycling , the SMH among all tested groups showed no significant difference ( P >0.05).After pH cycling, the SMH loss and lesion depth of 1 000 mg/L NaF and 7 000 mg/L HPN groups were not significantly different (P>0.05), but significantly lower than those in other 3groups (P<0.05).CONCLUSION:The orange juice is erosive to dentin.Hesperidin at 7 000 mg/L can inhibit the demineralization of human coronal dentin.
Keywords：hesperidindental erosionhuman dentinanti-demineralizationsurface micro-hardness
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 513-517,541 )