Influence of apigenin on the cariogenicity of Streptococcus mutans
LI Bei-lei
YUE Yang-li
LIU Yao
LIU Xue-jun
Abstract：AIM:To study the effects of apigenin on the cariogenicity of Streptoccous mutans (S.mutans). METHODS:S.mutans ATCC25175 cells were treated by apigenin at the concentration (μg/mL)of 12.5,25,50, 100,200 and 400 respectively,and TPY liquid medium was used as the control.Bacteriostatic experiment was conduc-ted by disc diffusion method.PH value drop quantity,adhesion inhibition rate,glucanotransferase (GTF)vitality and the content of insoluble exopolysaccharides were measured in every groups.RESULTS:Apigenin solution at the vari-ous concentrations showed no effect on the proliferation and anaerobic acidogenesis of the bacteria.With the increase of apigenin concentration the adhesion inhibition rate of S.mutans increased,while GTF vitality and insoluble exopolysac-charides content decreased(P<0.05).CONCLUSION:Apigenin has no inhibition effect on the proliferation and acid production of S.mutans.However,it can inhibit the adhesion ability,GTF enzymes activity and insoluble exopo-lysaccharides production of S.mutans.
Keywords：apigeninstreptococcus mutanscariogenicityacid productionadhesionglucanotransferaseisol-uble exopolysaccharides
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 377-380 )