Impact of ovariectomy on the mandibular alveolar bone mineral density and experimental periodontitis
YAN Cheng-wei
AN Jing-tao
LI Ying
ZHANG Bin
JIN Xing-ai
LIU Ying-qun
Abstract：AIM:To investigate the impact of ovariectomy on mandibular alveolar bone mineral density and periodontal disease.METHODS:Twenty 12-week-old female Wistar rats were randomly assigned into sham surgery (SHAM)group and ovariection(OVX)group (n=10).3 months after surgery,periodontal disease was induced by silk ligature around the neck of the mandibular right first molar for 2 months.Then the rats were sacrificed,Micro-CT scan was carried out to detect the bone mineral density (BMD),trabecular thickness (Tb.Th),bone volume fraction (BV/TV),trabecular separation (Tb.Sp.)and bone surface to bone volume (BS/BV)of mandibular alveolar bone. Alveolar bone height loss (ABHL)was measured on 3D models.RESULTS:5 months after ovariectomy,the values BMD,Tb.Th and BV/TV in OVX rats were lower than those in SHAMrats (P<0.05),whereas the values of Tb.Sp and BS/BV of the OVX rats increased compared with SHAM rats (P<0.05 ).However,no difference was found in ABHL between 2 groups.CONCLUSION:Ovariectomy induces osteoporosis in the mandibular alveolar bone of rats, but has no effect on the alveolar bone height loss of rats with experimental periodontitis.
Keywords：ovariectomyalveolar bone lossexperimental periodontitisMicro-CT
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 282-285 )