Osteogenetic effects of two acellular dermal matrix materials on GBR of rabbit skull defect
CHEN Chang-xing
SONG Xiao-ling
DA Jing-shu
CHEN Wu
Abstract：AIM:To compare the effects of two acellular dermal matrix (ADM)materials on the repair of the rabbit skull defects.METHODS:A cycloid skull defect with the diameter of 8mm was made on both sides of the sagittal suture of 20 rabbits.The rabbits were randomly divided into 5 groups.The skull defects were treated with im-plantation of hydroxyapatite-tricalcium phosphate (HA-TCP)+porcine ADM (P-ADM ),HA-TCP +bovine ADM (B-ADM,Haoao Biofilm ),HA-TCP +Bio-gide collagen membrane,HA-TCP and wihtout implantation (control) respectively.After 8 and 12 weeks,10 rabbits were sacrificed respectively and the bone samples were were examined by HE staining and Masson staining.RESULTS:Both P-ADM and B-ADM could play a role as barrier membrane in guiding and promoting osteogenesis in rabbit skull defects.There was no significant difference between B-ADMand Bio-gide collagen membrane in promoting osteogenesis at 8 and 12 weeks after treatment(P>0.05).P-ADMimplanta-tion produced less osteogenesis than B-ADM and Bio-gide at 8 and 12 weeks after treatment(P<0.05 ),but more than HA-TCP and control(P<0.05).CONCLUSION:Both P-ADMand B-ADMcan promote osteogenesis in bone defect.
Keywords：guided bone regenerationacellular dermal matrixrabbit skull defect models
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 274-277 )