Expression of COX-2 and iNOS in gingival tissues of patients with chronic periodontitis
QI Hong-Yan
CHEN Li-Ya
ZHANG Zhi-rui
Abstract：AIM: To evaluate the cyclooxgenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in periodontal tissues. METHODS:Fifteen patients with chronic periodotitis (CP), 15 patients with gingivitis (G) and 15 health controls (H) were included in this study. Gingival tissues were surgically excised. COX-2 and iNOS expression were detected with immunohistochemistry staining. RESULTS:COX-2 and iNOS were not detected in healthy gingival tissues. Positive staining of COX-2 and very strong positive staining of iNOS were detected in the ginvival tissues of CP and G groups. The expression of COX-2 in CP group was significantly higher than that in H group (P<0.05). No significant difference of COX-2 expression was found between the CP and G group, and also between the G and H group (P>0.05). The expression of iNOS in CP and G group was significantly higher than that in H group (P<0.05). No significant difference of iNOS expression was found between the CP and G groups (P>0.05). CONCLUSION: COX-2 and iNOS expression ware elevated in the inflamed gingival tissues of gingivitis and chronic periedontitis. COX-2 and iNOS may play important roles in the destruction of periodontal tissues.
Keywords：cyclooxygenase-2 (COX-2)inducible nitric oxide synthase (iNOS)periodontitisimmunohisto-chemistry techniques
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 139-142 )