Effects of scutellarin on proliferation of LPS-treated human periodontal ligament cells
YANG Ning
ZHANG Ying
GE Zhi-hua
WANG Chun-yan
Abstract：AIM:To examine the effects of scutellarin on the proliferation of lipopolysaccharide(LPS)-trea-ted human periodontal ligament cells(hPDLCs).METHODS:Primary hPDLCs cultured in vitro were stimulated with100μg/mL LPS,and LPS plus various concentrations of scutellarin.hPDLCs without treatment senred as controls.After 24 h,48 h and 72 h incubation,MTY assay was performed to assess the effects of scutellarin on cell proliferation.Flow cytometry Was used to measure the DNA content after 24 h of incubation.RESULTS:LPS significantly inhibited the proliferation of hPDLCS.Scutellarin dose-dependently stimulated the growth of LPS-treated hPDLCs at different time points,and the optimal stimulating effect of scutellarin was 1μg/mL(P<0.05).CONCLUSION:Scutellarin Can significantly promote the proliferation of LPS-treated hPDLCs.
Keywords：scutellarinhuman periodontal ligament cellLPScell proliferationcell cvcle
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )