Effect of increased occlusal force on the expression of IL-6 mRNA in the rat periodontium
YUAN Lin
ZHOU Wei-dong
ZHAO Yun-feng
Abstract：AIM: To study the expression of IL-6 mRNA in rat periodontal ligament cells (PDLC) and osteoblasts under different occlusal forces, in order to explain the molecular mechanism of periodontium remodeling. METHODS: A rat model of different occlusal force was established by extracting the left maxillary molars, so that the left mandibular molar area was used as the bite force lost model and the right mandibular molar area as the bite force increased model. The untreated rats' mandibular molar area used as normal bite force model. The prepared tissue specimens were processed to study the expression of IL-6 mRNA in PDLC and osteoblasts with in situ hybridization technique. RESULTS: In the group of increased occlusal force the expression of IL-6 mRNA in PDLC and osteoblasts enhanced apparently than the group of normal occlusal force. CONCLUSION: The result of the increased occlusal force enhanced the expression of IL-6 mRNA in PDLC and osteoblasts suggested that the IL-6 may play important roles in the process of periodontium remodeling initiated by different occlusal force.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 160-162 )