The expression of Smad1，4，5 in human dental pulp tissue
Abstract：AIM：To observe the expression of Smad1，4，5 in h uman dental pulp tissue of normal, carious and inflammatory couditions, and explore the effect of Smad1，4，5 on dental pulp repair after tissue injury. METHODS: The expression and distribution of Smad1，4，5 in dental pulp tissue were detected by using immunohistochemical technique. R ESULT S: Strong specific staining for Smad1，4，5 was detected in the odont oblasts of normal and carious teeth. Weaker staining was observed in the u nderlying cell-rich layer and pulp core. The inflammatory cells at the si tes of pulp inflammation were Smad1，4，5 strongly stained. Among the three transducers , the expression of Smad4 was the highest one in all specimens and that of Smad5 was the lowest. CONCLUSION: Smad1，4，5 might play an role in BMP intracellular sign aling for regulating the differentiation of the odontoblasts.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 82-85 )