Immunohistochemical study of TGF-β1, TGF-β2 and TGF-β3 protein expressions in human tooth germs
SU Ling-yun
WU Bu-ling
SHI Jun-nan
Abstract：AIM: Study of the effect of TGF-β1, TGF-β2 and TGF-β3 in the human tooth development.METHODS: SP HC was used to detect the localization of TGF-β1, TGF-β2 and TGF-β3 protein on human tooth germs sections(16th to 28th gwk). RESULTS: TGF-β1 and TGF-β3 mainly expressed in ameloblasts and odontoblasts. TGF-β2mainly expressed in inner enamel cells and ameloblasts. TGF-β1 、TGF-β2 and TGF -β3 demonstrated positive expression in the enamel knot. CONCLUSION: TGF-β1、TGF-β2 and TGF-β3 are important regulators in the human tooth development. They are involved in tooth germ cytodifferention, promote the secretion of the dentin matrixes, and regulate the tooth morphogeny.
Keywords：transforming growth factor βtooth germscytodifferentiationtooth development
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 307-309 )