Release of doxycycline from a sustained- release drug delivery system In vitro and vivo
ZHANG Wei-xin
LIANG Yi-hui
DENG Shu-hai
Abstract：AIM: To prevent or at least to reduce the bacterial colonization on barrier membranes during the period of membrane retention, a local sustained- release drug delivery system (SRDDS) for antibiotic was developed. The drug release behavior of such a SRDDS in vitro and in vivo was evaluated in this study. METHODS: In vitro, 6 units of SRDDS were respectively placed into PBS and the amount of daily drug release were measured by UV- spectrophotometry. In vivo, 6 units of SRDDS were respectively implanted into parietal bone defects of 6 rabbits. The concentration of drug adjacent to the defects was measured by a bioassay technique. REAULTS: In vitro, antibiotics could be steadily released from SRDDS andabout 63 % of the drug had been released by the day 28. In vivo, a unit of SRDDS could steadily release drug in effective concentration for at least 6 weeks. CONCLUSION: When the SRDDS was used underneath the barrier membranes, it seems to be able to prevent or at least reduce the bacterial colonization on the barrier membranes.
Keywords：drug delivery systemhydroxyapatitedoxycyclineguided tissue regeneration
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 276-279 )