Research progress of itaconic acid and its derivatives in sepsis
Nan Longteng
Wang Congrui
Hou Man
Zhang Wen-kai
Abstract：Sepsis is multi-organ dysfunction due to a dysregulated response to infection.Due to the high morbidity,high mortality and high treatment costs,and the lack of effective treatment methods,the global medical burden has become in-creasingly serious in recent years,so it is imperative to explore the mechanism of the occurrence and development of sepsis and find new therapeutic drugs that may improve or prevent the occurrence and development of sepsis.Studies have found that itaconic acid,as a naturally occurring metabolite in immune cells,plays an important role in regulating inflammation and im-mune metabolism,and may be a very promising drug for the prevention and treatment of sepsis.This article reviews the re-search progress on the mechanism of action and efficacy of itaconic acid in the treatment of sepsis and the protection of multi-organ function,in order to provide more ideas and help for the research and treatment of sepsis.
Keywords：SepsisMultiple organ dysfunction syndromeItaconic acidOrgan protectionInflammation
Publication Date：2026-03-18
Online Publishing Date：2026-04-08(First online date of this platform, not the publication date of the document)
Pages：5( 380-384 )