Research progress and prospect of CAR-NK cell combined therapy for prostate cancer
Li Xin
Mo Ren
Jia Jian-chao
Chi Ning
Abstract：Chimeric Antigen Receptor Natural Killer(CAR-NK)cells as a new strategy for immunotherapy of prostate cancer.This article reviews the construction of CAR-NK cells with prostate-specific Membrane Antigen(PSMA)and Prostate Stem Cell Antigen(PSCA)as key targets.Significant anti-tumor effects achieved in preclinical studies.At the same time,strategies such as optimizing the CAR structure,combining immune checkpoint inhibitors,and molecular targeted drugs were explored to enhance efficacy and safety.Despite the challenges in clinical translation,CAR-NK cell therapy is expected to offer a new treatment option for patients with prostate cancer.This article provides a comprehensive review of the research progress of CAR-NK cell technology in the treatment of prostate cancer.
Keywords：Prostate cancerChimeric antigen receptor natural killer cellsImmunotherapyTargeted therapyCom-bined therapy
Publication Date：2026-03-18
Online Publishing Date：2026-04-08(First online date of this platform, not the publication date of the document)
Pages：6( 374-379 )