Research progress of circulating microorganisms in gastrointestinal tract tumors
An Junjie
Ren Yingzheng
Yang Yang
Dong Yonghong
Abstract：Gastrointestinal tumors are one of the leading causes of cancer-related deaths worldwide.Their initiation and progression are driven by the complex interactions of multiple factors including genetics,the environment and microbial ecology,posing a severe threat to human health.Current clinical treatments are plagued by marked interindividual variability in efficacy,along with a high risk of drug resistance and recurrence,making it an urgent priority to explore novel pathogenic mechanisms and therapeutic targets.With the development of technologies such as metagenomic sequencing,the traditional no-tion that the blood of healthy individuals and tumor patients is"sterile"has been overturned,and the role of circulating micro-organisms(CM)in gastrointestinal tumors has attracted widespread attention.CMs participate in the tumorigenesis and pro-gression of gastrointestinal tumors by regulating inflammation,immunity,and angiogenesis in the tumor microenvironment,of-fering a new perspective for clinical diagnosis and treatment.However,relevant research is still limited by technical drawbacks in detection,incomplete elucidation of specific mechanisms,and the lack of large-sample validation in clinical translation.Go-ing forward,it is necessary to optimize detection technologies,further decipher the molecular mechanisms underlying CM-me-diated regulation of gastrointestinal tumors,and conduct large-scale clinical studies to validate the diagnostic value of microbial biomarkers and the efficacy of targeted interventions,thereby providing new strategies for the precise prevention and treatment of gastrointestinal tumors.
Keywords：Gastrointestinal cancersCirculating MicroorganismsPathogenesisIntervention
Publication Date：2026-03-18
Online Publishing Date：2026-04-08(First online date of this platform, not the publication date of the document)
Pages：5( 369-373 )