Observations on the efficacy of laser photocoagulation with different treatment areas for proliferative diabetic retinop-athy
Zhang Lili
Yao Yueju
Feng Zhengguo
Liu Jie
Zhang Min
Abstract：Objective To compare the efficacy of pan-retinal,sectoral,and ischemic area-targeted laser photocoagu-lation in the treatment of proliferative diabetic retinopathy(PDR).Methods A prospective cohort study was conducted,en-rolling 88 PDR patients admitted to the Department of Ophthalmology,Bengbu Third People's Hospital from November 2021 to April 2025.According to the laser photocoagulation treatment area,patients were divided into the pan-retinal photocoagula-tion(PRP)group(n=28),the sectoral group(n=30),and the ischemic area-targeted group(n=30).Best corrected visual acuity(BCVA)was measured using the international standard visual acuity chart;central macular thickness(CMT)and foveal avascular zone(FAZ)area were measured by optical coherence tomography(OCT),and retinal nerve fiber layer(RNFL)thick-ness in the inferior,nasal,superior,and temporal quadrants around the optic disc was also measured.All measurements were taken preoperatively and 1 month postoperatively.The incidence of postoperative complications was recorded and compared among the groups.Results At 1 month postoperatively,BCVA(LogMAR)improved significantly in all three groups com-pared to preoperative levels(t=10.552,10.232,and 8.822,respectively;all P＜0.05).A significant difference in BCVA(Log-MAR)was observed among the three groups(F=11.825,P＜0.05).Pairwise comparisons revealed that the sectoral group achieved the lowest LogMAR values(indicating the best visual acuity),followed by the PRP group,while the ischemic area-targeted group showed the highest values(all P＜0.05).Postoperative CMT decreased in all three groups compared to preopera-tive levels(t=12.745,15.551,8.972,all P＜0.05),with a statistically significant difference in CMT among the three groups(F=26.019,P＜0.001).Pairwise comparisons showed the order of reduction was:sectoral group＜PRP group＜ischemic area-tar-geted group(all P＜0.05).In contrast,no significant differences were found in FAZ area before and after laser treatment in any group(all P＞0.05).After surgery,RNFL thickness in the inferior,nasal,superior,and temporal quadrants decreased in all three groups compared to preoperative levels,with the order of reduction being:sectoral group＜PRP group＜ischemic area-targe-ted group(allP＜0.05).The complication rates in the sectoral group(3.33％)and ischemic area-targeted group(6.67％)were significantly lower than that in the PRP group(28.57％)(x2=9.850,P=0.007).Conclusion Sectoral retinal laser photocoag-ulation is more conducive to improving visual acuity,reducing central macular thickness and retinal nerve fiber layer thickness in all quadrants in PDR patients,and is associated with a lower risk of complications,demonstrating safety and reliability.
Keywords：Proliferative diabetic retinopathyPan-retinal photocoagulationSectoral retinal photocoagulationIschemic area-targeted retinal photocoagulationVisual acuityTherapeutic effect
Publication Date：2026-03-18
Online Publishing Date：2026-04-08(First online date of this platform, not the publication date of the document)
Pages：6( 274-279 )