Effects of probiotics combined with aerobic exercise on metabolism and cardiopulmonary function in obese type 2 dia-betes patients
Wang Wei
Lan Lizhen
Liu Min
Du Rui
Abstract：Objective This study aims to explore the effects of aerobic exercise intervention combined with probiot-ics on metabolic indicators and cardiopulmonary function in obese patients with type 2 diabetes mellitus and metabolic syn-drome(T2DM-MS).Methods From August 2022 to August 2024,163 T2DM-MS patients who visited the Department of General Practice at First Hospital of Shanxi Medical University were assigned into a test group(aerobic exercise intervention combined with probiotics)and a control group(probiotics alone)using a random number table method,with 80 patients in each group.The changes in clinical parameters,blood glucose indicators,metabolic indicators,lung function,and heart function were compared between the two groups.Results After treatment,waist circumference and blood pressure decreased in both groups,with the test group showing significantly lower values than the control group(t/P=2.260/0.025,2.613/0.010,2.279/0.024,2.195/0.030).There was no significant change in BMI in the control group before and after treatment(P＞0.05),while BMI in the test group decreased and was significantly lower than that in the control group(t/P=1.988/0.049).FPG,HbA1c,and 2hPG decreased in both groups after treatment,with significantly lower levels in the test group compared to the control group(t/P=5.128/＜0.001,4.727/＜0.001,3.499/0.001).After treatment,TC,TG,and LDL-C in the test group decreased and were significantly lower than those in the control group(t/P=2.235/0.027,3.292/＜0.001,4.997/＜0.001),while HDL-C lev-els increased and were significantly higher than those in the control group(t/P=2.412/0.017).After treatment,forced vital ca-pacity(FVC),forced expiratory volume in one second(FEV1),and maximum voluntary ventilation(MVV)in the test group increased and were significantly higher than those in the control group.No statistically significant differences were observed in these pulmonary function indicators in the control group before and after intervention.After treatment,left ventricular ejection fraction(LVEF)in the test group increased(and was significantly higher than that in the control group),while left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)decreased(and were significantly lower than those in the control group).Compared with before intervention,no statistically significant differences were observed in various cardiac function indicators in the control group.Conclusion Aerobic exercise intervention combined with probiotics can significantly improve glucose and lipid metabolism indicators and cardiopulmonary function in patients with T2DM-MS,providing new insights for comprehensive intervention of this disease.
Keywords：Type 2 diabetes mellitusMetabolic syndromeObesityAerobic exercise interventionProbioticsGlucose and lipid metabolismCardiopulmonary functionTherapeutic effect
Publication Date：2026-03-18
Online Publishing Date：2026-04-08(First online date of this platform, not the publication date of the document)
Pages：5( 257-261 )