Research progress on the potential pathogenic mechanisms of ALS patients with FUS mutation
Wu Yanan
Li Jian-jun
Abstract：Amyotrophic lateral sclerosis(ALS)is a fatal disease characterized by the progressive degeneration of mo-tor neurons.Autosomal dominant mutations in the Fused in Sarcoma(FUS)gene,which encodes a DNA and RNA-binding protein,are one of the causes of ALS.Approximately 2.8％of familial ALS cases and some sporadic ALS cases are associated with FUS mutations,and this association is more common in the Asian population.Compared with other forms of ALS,FUS-mutation-associated ALS(FUS-ALS)is characterized by early onset and rapid progression,thus attracting increasing attention in clinical research.This article discusses the research progress on its potential pathogenic mechanisms around five key dimen-sions:nuclear homeostasis,RNA processing,neuronal function,stress response,and metabolic balance,with the aim of provi-ding insights for the treatment of FUS-ALS.
Keywords：Amyotrophic lateral sclerosisFused in sarcomaPathogenic mechanismsResearch progress
Publication Date：2026-02-18
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：5( 243-247 )