Expression and clinical significance of TP53 and STK11 in cervical cancer tissue

Wang Yiting; Tian Tingting; Li Lin; Zhang Yujie

doi:10.3969/j.issn.1671-6450.2026.02.015

Abstract：Objective To investigate the expression of tumor suppressor p53(TP53)and serine/threonine kinase 11(STK11)in cervical cancer tissues and adjacent tissues,with a focus on analyzing the correlation between TP53 and STK11 expression in cancer tissues and clinicopathological characteristics and prognosis.Methods A retrospective analysis was con-ducted on 113 cervical cancer patients who underwent surgical treatment at Heilongjiang Provincial Hospital from January 2018 to December 2022.The expression of TP53 and STK11 in cancer tissues and adjacent tissues was statistically analyzed,and postoperative follow-up data were reviewed.Patients were grouped according to their prognosis(recurrence and metastasis within 2 years after surgery),and the expression of TP53 and STK11 in cancer tissues was compared under different patholog-ical characteristics and prognosis conditions.Cox regression analysis,nomogram,and decision curve analysis were used to an-alyze the possible relationship between TP53 and STK11 expression and prognosis.Results The expression levels of TP53 mRNA and STK11 mRNA in cervical cancer tissues were lower than those in adjacent tissues(t/P=6.642/＜0.001,24.874/＜0.001).The International Federation of Gynecology and Obstetrics(FIGO)stage ⅡA and the proportion of lymph node metas-tasis in the recurrence group were higher than those in the non-recurrence group(x2/P=14.962/0.001,9.611/0.002).The ex-pression levels of TP53 mRNA and STK11 mRNA in the recurrence group were lower than those in the non-recurrence group(t/P=3.511/0.001,3.553/0.001).Multivariate Cox regression analysis revealed that FIGO stage ⅡA and lymph node metastasis were significant risk factors for cervical cancer recurrence[HR(95％ CI)=3.556(1.126-11.235),2.804(1.071-7.342)],while TP53 and STK11 demonstrated protective effects[HR(95％CI)=0.427(0.190-0.959),0.472(0.268-0.831)].The nomogram based on Cox regression analysis showed that a 0.05 decrease in TP53 mRNA expression level increased the postoperative re-currence risk of cervical cancer by 13.75 points,while a 0.05 decrease in STK11 mRNA expression level raised the risk by 12.50 points.The nomogram model predicted a C-index of 0.856(95％CI:0.794-0.917)for evaluating the risk of postopera-tive cervical cancer recurrence,indicating good model discrimination.Conclusion The low expression of TP53 and STK11 in cervical cancer tissues is associated with the risk of postoperative recurrence in patients and may serve as a novel biomarker for evaluating the prognosis of cervical cancer patients.