Expression and clinical significance of serum IL-6,MCP-1,and SAA in urinary tract infections after kidney stone surgery
Zhang Lei
Chen Hongrun
Zhang Lianfeng
Fu Taozhu
Abstract：Objective To investigate the expression and clinical significance of serum interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1),and serum amyloid A(SAA)in urinary tract infections(UTIs)after kidney stone surgery.Methods Between October 2023 and October 2024,187 patients who underwent Kidney Stone Surgery in Fuxing Hospital,Capital Medical University were recruited and divided into the UTI group(n=45)and the non-UTI group(n=142)based on whether UTI occurred postoperatively.Serum levels of IL-6,MCP-1,and SAA were detected using ELISA.A microbial analy-zer was used for pathogen detection and identification.Multiple logistic regression was applied to explore the influencing fac-tors of UTI occurrence.ROC curve analysis was used to evaluate the diagnostic value of serum IL-6,MCP-1,and SAA for UTI after kidney stone surgery.Results Compared with the non-UTI group,the UTI group had significantly higher serum levels of IL-6,MCP-1,and SAA(t=6.691,6.060,5.549,P＜0.05).A total of 65 strains of pathogenic bacteria were isolated from the urine of 45 postoperative UTI patients,including 22 strains of Gram-positive bacteria,38 strains of Gram-negative bacteria,and 5 strains of fungi.Preoperative placement of ureteral stent,prolonged indwelling time of urinary catheter,and ele-vated levels of IL-6,MCP-1,and SAA were identified as influencing factors for UTI occurrence[OR(95％CI)=2.453(1.527-3.942),3.023(1.580-5.784),4.112(3.168-5.337),3.786(2.058-6.965),4.978(2.859-8.669)].The AUC values of serum IL-6,MCP-1,and SAA levels alone and in combination for diagnosing postoperative UTI in patients with kidney stones were 0.753,0.766,0.832,and 0.931,respectively.The combination of the three markers was superior to their individual diagnostic values(Z=4.255,4.303,3.568,P＜0.001).Conclusion Serum IL-6,MCP-1,and SAA are highly expressed in patients with UTI after kidney stone surgery,and their combined detection can improve the diagnostic efficacy for UTI occurrence.
Keywords：Kidney stone surgeryUrinary tract infectionInterleukin-6Monocyte chemoattractant protein-1Serum amyloid A
Publication Date：2026-02-18
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：5( 191-195 )