Clinical value of serum LRG1 and S100A14 in predicting recurrence and metastasis after laparoscopic radical resec-tion of colon cancer

Xiao Gaochun; Hui Yuanjian; Li Jun; Tan Huayong; Xiang Feng; Liu Yanwei

doi:10.3969/j.issn.1671-6450.2026.02.009

Abstract：Objective To investigate the clinical value of serum leucine-rich alpha-2-glycoprotein 1(LRG1)and S100 calcium-binding protein A14(S100A14)in predicting recurrence and metastasis after laparoscopic radical resection of colon cancer.Methods A total of 220 patients with colon cancer who underwent laparoscopic radical resection at the Depart-ment of Gastrointestinal Surgery,Taihe Hospital,Shiyan from July 2020 to June 2022 were included as the colon cancer group,along with 90 patients with benign colon lesions who sought medical attention during the same period as the control group.The levels of serum LRG1 and S100A14 in biobank-stored samples were detected.Based on whether recurrence or me-tastasis occurred within 3 years after surgery,colon cancer patients were divided into a recurrence and metastasis subgroup and a non-recurrence and non-metastasis subgroup.Clinical data and the levels of LRG1 and S100A14 were compared between the two groups.Multivariate logistic regression analysis was employed to identify the influencing factors for recurrence and metas-tasis after laparoscopic radical resection for colon cancer.Receiver operating characteristic(ROC)curves were used to evaluate the predictive value of serum LRG1 and S100A14 levels for recurrence and metastasis after laparoscopic radical resection for colon cancer.Results The serum levels of LRG1 and S100A14 were higher in the colon cancer group than in the control group(t/P=24.094/＜0.001,29.156/＜0.001).Compared with the recurrence and metastasis subgroup,the non-recurrence and non-metastasis subgroup of colon cancer patients had a higher proportion of well-differentiated/lower proportion of poorly dif-ferentiated tumors,a higher proportion of TNM stage Ⅰ+Ⅱ/lower proportion of stage Ⅲ,a lower proportion of lymph node metastasis,and lower levels of LRG1 and S100A14(x2/t/P=23.979/＜0.001,11.324/0.001,22.861/＜0.001,5.990/＜0.001,6.469/＜0.001).Poor differentiation,TNM stage Ⅲ,lymph node metastasis,and high levels of LRG1 and S100A14 were risk factors for postoperative recurrence and metastasis[OR(95％CI)=25.953(3.077-218.923),10.057(1.151-87.835),3.231(1.379-7.569),1.041(1.023-1.060),1.481(1.249-1.756)].The areas under the curve(AUCs)for serum LRG1,S100A14 levels,and their combination in predicting postoperative recurrence and metastasis in colon cancer patients were 0.760,0.758,and 0.833,respectively.The combined prediction was superior to the individual predictive values(DeLong method was used to compare the differences)(Z=2.921,2.647;P=0.003,0.008).Conclusion The levels of serum LRG1 and S100A14 are closely related to recurrence and metastasis after laparoscopic radical resection of colon cancer and can be used as risk factors to predict the risk of recurrence and metastasis after laparoscopic radical resection of colon cancer.