Expression and clinical significance of serum sTREM2 and PDGFR-β levels in patients with coronary microvascular dysfunction
Tan Feng
Lu Qianqian
Li Pingzhen
Zhang Yuan
Liu Kejian
Abstract：Objective To investigate the expression and clinical significance of peripheral blood soluble triggering receptor expressed on myeloid cells 2(sTREM2)and platelet-derived growth factor receptor-β(PDGFR-β)in patients with coronary microvascular dysfunction(CMD).Methods A total of 126 patients with non-obstructive angina pectoris(ANOCA)admitted to the First Affiliated Hospital of Shihezi University from January 2022 to December 2024 were prospec-tively selected and divided into CMD group(61 cases)and non-CMD group(65 cases)according to coronary flow reserve(CFR)and/or microcirculation resistance index(IMR).The caliper matching method was used to match the CMD group and the non-CMD group by 1∶1(matching tolerance 0.03),and 46 pairs of balanced samples of variables between groups were fi-nally obtained.The levels of sTREM2 and PDGFR-β in peripheral blood were detected by enzyme-linked immunosorbent as-say.Pearson correlation analysis was used to analyze the correlation between sTREM2 and PDGFR-β levels in peripheral blood of CMD patients after PSM and CFR and IMR.Multivariate Logistic regression and ROC curve were used to analyze the relationship between peripheral blood sTREM2,PDGFR-β levels and CMD occurrence and diagnostic value.Results Compared with the non-CMD group,the serum sTREM2 and PDGFR-β levels in the CMD group were increased(t=5.447,4.906,P＜O.00l);the levels of sTREM2 and PDGFR-β in peripheral blood of CMD patients were negatively correlated with CFR and positively correlated with IMR(r=-0.734,-0.725;0.739,0.714;all P＜0.001);After adjusting for confounding fac-tors,high sTREM2 and high PDGFR-β were independent risk factors for CMD[OR(95％CI)=1.006(1.003-1.010),1.601(1.232-2.081)];The area under the curve of sTREM2 and PDGFR-β levels in peripheral blood and the combined diagnosis of CMD were 0.784,0.768 and 0.870,respectively.The combined diagnosis value was better than that of the single diagnosis val-ue(Z=2.297,2.615,P=0.022,0.009).Conclusion The elevated levels of sTREM2 and PDGFR-β in peripheral blood of ANOCA patients are closely related to CMD.The combination of sTREM2 and PDGFR-β levels in peripheral blood has a high diagnostic value for CMD.
Keywords：Angina with non-obstructive coronary arteriesSoluble triggering receptor expressed on myeloid cells 2Platelet-derived growth factor receptor-βCoronary microvascular dysfunctionDiagnosis
Publication Date：2026-02-18
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：6( 156-161 )