Relationship between serum Sirt1,Sirt6 levels and diabetes in patients with diabetic cataract and its diagnostic value
Su Xuegang
Zhao Kuo
Ni Jun
Guan Zheng
Zhang Xuemin
Abstract：Objective To investigate the relationship between the levels of serum sirtuin 1(Sirt1)and sirtuin 6(Sirt6)and diabetes in patients with diabetic cataract(DC)and its diagnostic value.Methods A total of 113 patients with DC admitted to the Ophthalmology Department of Shunyi District Maternal and Child Health Hospital,Beijing,from January 2024 to June 2025 were prospectively enrolled(DC group).In addition,113 patients with type 2 diabetes mellitus(T2DM group)and 113 healthy individuals(control group)matched at a 1∶1 ratio were included.Serum Sirt1 and Sirt6 levels were measured using enzyme-linked immunosorbent assay.According to the stage of cataract,DC patients were divided into early(n=34),middle(n=43),and late(n=36)subgroups.Spearman correlation analysis was used to assess the association between serum Sirt1,Sirt6 levels and DC stage.Multivariate logistic regression was performed to identify factors influencing DC occurrence.Receiver operating characteristic(ROC)and decision curve analyses were used to evaluate the diagnostic performance and clinical benefit of serum Sirt1 and Sirt6 levels.Results Serum Sirt1 and Sirt6 levels decreased progressively across the con-trol,T2DM,and DC groups(F/P=312.468/＜0.001;257.992/＜0.001),and further declined with advancing DC stage(F/P=240.406/＜0.001;158.124/＜0.001).Serum Sirt1 and Sirt6 levels were negatively correlated with DC stage(rs/P=-0.653/＜0.001;-0.680/＜0.001).Longer T2DM duration and higher HbA1c were independent risk factors for DC,while increased Sirt1 and Sirt6 levels were independent protective factors[OR(95％CI)=1.741(1.329-2.282),2.217(1.241-3.960),0.692(0.606-0.791),0.720(0.636-0.815)].The areas under the ROC curve for serum Sirt1,Sirt6,and their combination in diagnosing DC were 0.808,0.796,and 0.901,respectively.The combined diagnostic model performed better than either marker alone(Z/P=3.692/＜0.001;4.428/＜0.001).Decision curve analysis showed that within a threshold probability range of 0.15-0.95,the com-bined model yielded greater net clinical benefit than individual Sirt1 or Sirt6 levels.Conclusion Serum Sirt1 and Sirt6 levels are significantly decreased in DC patients and are associated with disease occurrence and progression.The combined detection of Sirt1 and Sirt6 provides superior diagnostic performance and clinical benefit,suggesting potential value for early diagnosis and risk assessment of diabetic cataract.
Keywords：Diabetic cataractSirtuin 1Sirtuin 6Diagnostic performance
Publication Date：2026-02-18
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：6( 140-145 )