Molecular mechanisms and targeted intervention strategies of mitochondrial oxidative stress in non-alcoholic fatty liver disease
Shang Lijing
Zhang Yi
Abstract：Non-alcoholic fatty liver disease(NAFLD),one of the most prevalent chronic liver diseases worldwide,has complex etiology and lacks effective treatment.Recent studies have shown that mitochondrial oxidative stress plays a key role in the development of NAFLD.The review presents the sources and biological basis of mitochondrial oxidative stress,systematically elucidates its mechanisms of mediating liver damage through multiple pathways such as inflammatory activation,programmed cell death,and autophagy dysfunction,and summarizes the current main intervention strategies targe-ting this process,including antioxidants,mitochondrial-targeted drugs,natural bioactive compounds,and signaling pathway regulation.On this basis,we further compared the action levels and mechanistic differences among various intervention strate-gies,analyzed the challenges faced by current research and proposed future research priorities and directions,with the aim of providing theoretical support and research ideas for the mechanism research and intervention strategies of NAFLD.
Keywords：Non-alcoholic fatty liver diseaseOxidative stressMitochondriaReactive oxygen speciesMolecular mechanismsIntervention strategies
Publication Date：2026-01-18
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：5( 106-110 )