The predictive value of joint detection of serum DJ-1,Kallistatin,and TP53 for major adverse cardiovascular events in patients with acute myocardial infarction after PCI

Yang Lu; Li Li; Wang Huri; Wang Guoqiang; Wang Yueping

doi:10.3969/j.issn.1671-6450.2026.01.003

Abstract：Objective To analyze the predictive value of serum Parkinson's disease protein 7(DJ-1),kallikrein in-hibitor(Kallistatin)and tumor protein P53(TP53)for major adverse cardiovascular events(MACE)after percutaneous coro-nary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods From January 2024 to October 2024,102 patients with AMI admitted to the Department of Cardiovascular Medicine of Inner Mongolia Baogang Hospital were se-lected as the AMI group,and 100 healthy volunteers who underwent physical examination in the hospital during the same pe-riod were selected as the healthy control group.Serum levels of DJ-1,Kallistatin and TP53 were detected by ELISA.The AMI patients were followed up for 6 months,and the occurrence of recurrent MACE was recorded.Patients with recurrent MACE were assigned to the poor prognosis subgroup,while the rest were classified into the good prognosis subgroup.The Pearson method was used to analyze the correlation between serum DJ-1,Kallistatin and TP53.Logistic regression was performed to identify risk factors for poor prognosis in AMI patients,and ROC curve analysis was used to evaluate the predictive efficacy for poor prognosis.Results The serum levels of DJ-1(t=7.397,P＜0.001)and Kallistatin(t=7.632,P＜0.001)in the AMI group were lower than those in the healthy control group,while the level of TP53 was higher(t=7.978,P＜0.001).The serum levels of DJ-1(t=8.534,P＜0.001)and Kallistatin(t=7.737,P＜0.001)in the poor prognosis subgroup were lower than those in the good prognosis subgroup,while the level of TP53 was higher(t=7.382,P＜0.001).Serum DJ-1 was positively correlated with Kallistatin levels,and serum TP53 was negatively correlated with DJ-1 and Kallistatin levels(r=0.513,-0.467,-0.451,all P＜0.001).Low serum DJ-1[OR(95％CI)=0.714(0.577-0.884)],low Kallistatin[OR(95％CI)=0.692(0.553-0.865)],and high TP53[OR(95％CI)=2.315(1.296-4.135)]were risk factors for poor prognosis in AMI patients.The AUC values of serum DJ-1,Kallistatin,TP53 alone and their combination for predicting recurrent MACE in AMI patients were 0.795,0.796,0.807 and 0.917,respectively.The AUC of the combined three biomarkers was larger than that of each individual bio-marker(Z=2.931,2.900,2.640,P=0.003,P=0.004,P=0.008).Conclusion In AMI patients with recurrent MACE after PCI,serum DJ-1 and Kallistatin levels are lower and TP53 levels are higher compared to those without recurrent MACE.The com-bined detection of these three biomarkers can effectively predict the risk of recurrent MACE in AMI patients after PCI.