Expression of peripheral blood PTGS1 and MYL4 in patients with atrial fibrillation and its correlation with thrombo-embolic risk
An Rong
Mao Jianmei
Yang Kairong
Li Zhi
Bi Yun
Abstract：Objective To investigate the expression of prostaglandin-endoperoxide synthase 1(PTGS1)and myosin light chain 4(MYL4)in peripheral blood of patients with atrial fibrillation(AF),and their correlation with thromboembolic(TE)risk.Methods A prospective study enrolled 125 AF patients admitted to the Cardiovascular Center of Yan'an Universi-ty Affiliated Hospital from January 2022 to February 2024(AF group)and 125 age-and sex-matched healthy volunteers(con-trol group)at a 1∶1 ratio.AF patients were followed for 1 year and divided into TE and non-TE subgroups according to the occurrence of TE events.Peripheral blood PTGS1 and MYL4 levels were measured by enzyme-linked immunosorbent assay.Spearman correlation analysis was performed to assess the relationship between PTGS1,MYL4 levels and CHA2DS2-VASc scores in AF patients.Multivariate logistic regression and receiver operating characteristic(ROC)curve analysis were used to evaluate the association and predictive value of PTGS1 and MYL4 levels for TE risk in AF patients.Results Compared with the control group,AF patients exhibited higher PTGS1 and lower MYL4 levels in peripheral blood(t=13.543,-12.316;both P＜0.001).During the 1-year follow-up,the incidence of TE events in AF patients was 30.40％(38/125).Compared with the non-TE subgroup,patients in the TE subgroup were older,had a higher prevalence of diabetes,heart failure,prior IS/TIA,higher CHA2DS2-VASc scores,elevated PTGS1,and decreased MYL4 levels(x2/t=3.010,4.848,7.430,10.944,8.009,5.796,-5.738;P=0.003,0.028,0.006,0.001,＜0.001,＜0.001,＜0.001).PTGS1 levels were positively correlated with CHA2DS2-VASc scores,while MYL4 levels were negatively correlated(rs=0.702,-0.678;both P＜0.001).Advanced age,pri-or IS/TIA,high CHA2DS2-VASc score,and elevated PTGS1 were independent risk factors for TE in AF patients,whereas higher MYL4 was an independent protective factor[OR(95％CI)=1.154(1.035-1.286),3.663(1.578-8.500),1.857(1.316-2.620),2.335(1.481-3.681),0.864(0.801-0.931)].The area under the curve(AUC)for PTGS1,MYL4,and their combina-tion in predicting TE risk were 0.812,0.775,and 0.894,respectively,with the combined prediction significantly superior to ei-ther marker alone(Z=2.726,3.367;both P＜0.001).Conclusion Elevated peripheral blood PTGS1 and decreased MYL4 lev-els are associated with increased TE risk in AF patients.The combined assessment of PTGS1 and MYL4 provides higher pre-dictive efficacy for TE events.
Keywords：Atrial fibrillationThromboembolismProstaglandin-endoperoxide synthase 1Myosin light chain 4Prediction
Publication Date：2026-01-18
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：6( 2-7 )