Research progress on the changes of intestinal flora and their association with body's injury or adaptation in plateau environments
Xin Yu
Wang Gege
Chen Keming
Jing Linlin
Abstract：Intestinal flora,as the largest bacterial reservoir in the human body,serves as a critical microbial barrier and plays a vital role in maintaining internal homeostasis and host health.The living environment significantly influences the structural composition of the intestinal flora.When the body is exposed to the hypobaric hypoxic(HH)environments in the plateau region,the intestinal flora may become imbalanced due to high-altitude-related damage,while the body's adaptation can also drive convergent evolution of the microbiota.Specific interventions such as probiotics,prebiotics,or fecal microbiota transplantation can modulate the intestinal flora to some extent,thereby enhancing the body's adaptation to high-altitude envi-ronments and mitigating HH-induced tissue damage.This review summarizes domestic and international literature on the chan-ges in intestinal flora under plateau environments and their association with the body's damage and adaptation,aiming to provide new insights and strategies for the prevention and treatment of plateau injury and the regulation of physiological adaptation.
Keywords：Intestinal floraPlateau environmentPlateau injuryPlateau adaptation
Publication Date：2025-12-18
Online Publishing Date：2026-01-08(First online date of this platform, not the publication date of the document)
Pages：5( 1532-1536 )